Dr. Gregory House is a highly skilled diagnostician heading the Department of Diagnostic Medicine at Princeton–Plainsboro Teaching Hospital in New Jersey. He holds board certifications in both infectious disease and nephrology.

House is renowned for his exceptional medical intuition and problem-solving abilities, often solving complex cases that baffle other physicians. However, his brilliance is accompanied by a challenging personality. He is often described as irascible, rude, misanthropic, and selfish.

Physically, House is notable for his limp, a result of an infarction in his right leg, which necessitates the use of a cane and contributes to his chronic pain and subsequent addiction to painkillers.

Despite his abrasive demeanor and disdain for social niceties, House's unorthodox methods and relentless pursuit of medical puzzles make him an indispensable figure in his field. His complex character embodies the archetype of the brilliant but troubled genius, leaving a lasting impact on those around him.