The game saves fine. Probably you just have a Windows "Controlled Folder Access" function activated and didn't properly configure it. Another possible issue is that some sort of folder synchronization is active and running in the background. Something like OneDrive, Dropbox, etc.

Thanks for the answer, but pardon, what is "Controlled Folder Access"? And why th should file sync interfere with saving a game, let alone this one being the only one ever with issues?

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what is "Controlled Folder Access"?

https://learn.microsoft.com/en-us/defender-endpoint/enable-controlled-folders

https://support.microsoft.com/en-us/windows/allow-an-app-to-access-controlled-folders-b5b6627a-b008-2ca2-7931-7e51e912b034

https://www.computerworld.com/article/1612084/windows-controlled-folder-access-think-twice-before-deploying.html

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why th should file sync interfere with saving a game, let alone this one being the only one ever with issues?

Problems with saving game files in conjunction with synching programs were confirmed many times in the past. Kentucky Route Zero even made an extra update to move existing files from the "My Documents" (also the default save location for Wolf Among Us) folder to their present location.

https://gtm.you1.cn/app/1180660/discussions/0/2912094978023710705/?ctp=34#c4410795727365830646

Also note "should" vs. "could" vs. "must"!

CFA is off and I have not touched it. Other games do fine.
Please note that my first language is not English, however interference between a game (not) saving and a daemon syncing completely different files is very, very improbable. There is a 8 core CPU and NVME drives at work. With all due respect it is the same level of advice as "blow out the dust from your cooler". Thanks for taking the time to try to help me though.

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With all due respect it is the same level of advice as "blow out the dust from your cooler".

I am actually not giving you any advice. I am only mentioning the potential causes based on the experiences of other gamers here and elsewhere. I personally never had a problem with some games not saving, not starting, or such, but my computers are also properly configured. Every computer is configured differently, and there is no instant answer.

This "temporarily locked files" issue is as old as the file syncing programs, and anybody who studied IT can confirm it to you. Is it a problem in your case is again another story.

The eight-core CPU and NVME drive are irrelevant to the matter. 

Another possible cause:

Maybe your game does not save because of non-English characters in the save game path.

https://www.pcgamingwiki.com/wiki/The_Wolf_Among_Us
https://gtm.you1.cn/app/250320/discussions/0/810938082271038978/
https://gtm.you1.cn/app/250320/discussions/0/1473095331485841374/

(Path contains illegal characters; File access-related issues)
https://support.gog.com/hc/en-us/articles/213528789-Wolf-Among-Us-The?product=gog

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Game not saving?

Everytime I open the game, I have to start chapter 1 (?), where I have to talk to my piggy flatmate? I read something might be broken with the saving, is there a solution?

A fresh installation of the game saves fine on a fresh (properly set up) installation of Windows 11, on lousy 2014 hardware. No tweaks needed. As of today, 13:30.

https://ibb.co/nkd8ntn