I will say that, having played through the game for the first time with this update, the sword enemies at the shrine are the only ones I would consider frustrating. The blue laboratory bulbs are annoying to shoot, but they aren't very dangerous.

A lot of characters don't seem to be able to jump high enough to shoot them, and their collision hitbox is big enough to where I often accidentally bump into them due to the misleading isometric perspective.

Their ground aoe goes out extremely fast and has such a large hitbox that it's very difficult to predict and avoid it, whilst also leaving you very little time to shoot and deal damage to them before they reset into the air again. I sometimes seem to take damage even when I'm standing outside of the AOE markers.

They often spawn in multiples alongside other enemies, which doubles the stress of their massive aoe attacks whilst you are running from other pursuing enemies simultaneously.

They often take so long to die that they make the arena rooms feel impossible to complete in time. If chunks shows up mid fight it's even worse.

I am comfortably able to fight pretty much every other enemy in the game, but the shrine feels harder than the new dream levels, which is weird since it's supposed to be an early run stage that you use to loop your run quickly.