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If you're asking how best to do a setup run with the Marine, then pick one weapon to actually fight with and leave the others alone. Take off your armor if you want to deposit it. Go from the surface (or whichever room you start from) and try to make a straight shot for the target blue room. Marine is good for this since he has lots of health and does good damage. Don't be afraid to use some things in a tight situation - grenades or more powerful guns - since it's better to use some resources than to die and waste the run.
The same can be said of any roguelike, in my experience. You'll always find equipment that is super amazing... for other characters. And you'll never find the one thing that you're actually looking for. I wish Crawl or ADOM had this kind of solution so that I don't end up traversing two-thirds of the game without shoes, or so that when I find some super amazing artifact I can't use I can at least pass it to someone who can.
To be fair though, the original concept is probably from super oldschool roguelikes like NetHack where dead characters would produce lootable graves, allowing you to take items from other runs. This is like that but without requiring your characters to die to transfer stuff.
Pit's RNG code is a mess. Instead of fixing it devs added Blue Room as a "solution".