Make Him Mad: Deface the Louisiana Chapel



Act 1 - Louisiana
Level - Sanctuary

This is the very first level where you are given control of Rayne. As Mynce goes inside the Chapel, go outside and jump up to the roof of the Chapel where there will be a cross. That is what you need to destroy.

Big Momma: Kill Queen of the Underworld



Act 1 - Louisiana
Level - Queen of the Underworld
Defeat the boss.

Strategy - Dismember the legs first. Then activate Blood Rage and kill her when she falls down. Don't use guns as they do very little damage to the boss.

Ark of the Covenant: Find the Ark of the Covenant



Act 2 - Argentina
Level - Communication Breakdown

Strategy - This is in the level where you are tasked with destroying the communications of the GGG. When you reach this level a cut scene will play where a general goes down an elevator/lift and a soldier then runs off with the battery. Jump a floor down, turn around and go through the door opposite the flag. Upon entering there will be a single wooden box. Destroy the box and the Ark of the Covenant will be revealed

Thule Chapel: Kill Von Blut



Act 2 - Argentina
Level - Thule Chapel
Defeat Von Blut

Strategy - Ambush and try to go behind his armored podium. And then activate the ability to slow down time (Dilated Vision) and shoot him with your guns. Using Blood Rage is not that effective. Also one or two guards will spawn periodically, use them to regain health.

The Butcheress: Kill Dr. Bathory Mengele



Act 2 - Argentina
Level - Hell Hall
Defeat The Butcheress

Strategy - Use Blood Rage, she also tries to run away like Von Blut but you can catch up to her easily. Also beware of the falling platforms.

Walls of Jericho: Kill D. Mauler



Act 2 - Argentina
Level - Walls of Jericho
Defeat Mauler

Strategy - You can exploit his slow speed to get some hits in and then back off to build up your Rage. Once you have your Rage meter full, activate it and you can get him to low health pretty easily. But beware as even in Rage mode Mauler can hurt you.
Also some guards will be spawning regularly, you can use them to get your health back.

Teachers and Traitors: Kill Mynce



Act 3 - Germany
Level - Teachers and Traitors
Defeat Mynce

Strategy - The fight is divided into two parts. The first part happens on the stairs. Here you cant completely kill her, because after reaching a certain HP point Mynce will stop fighting you and run up the stairs. Then you just follow her up to the top. The second part starts when Mynce reaches the top and the door closes behind you. Here you can defeat her easily.

Right Hand Man: Kill Sigmund Krieger first



Act 3 - Germany
Level - Doppleganger
Kill Sigmund Krieger FIRST

Strategy - Sigmund is blind in his right eye. It's hard to know which one is Sigmund once the battle starts. But on the bottom-left, where it shows the HP of both of the brothers, Sigmund's HP level will be on the top. After you have defeated Sigmund first, Simon will commit suicide right after.

Left of Centre: Kill Simon Krieger first



Act 3 - Germany
Level - Doppleganger
Kill Simon Krieger FIRST

Strategy - Again its hard to know who is Simon once the battle starts. But on the bottom left where it shows the HP of both the brothers Simon's HP level will be on the bottom. After you have defeated Simon first, Sigmund will commit suicide right after.

Of Wulfs and Demons: Kill Beliar and Wulf



Act 3 - Germany
Level - Of Wulfs and Demons

Strategy - You should target Beliar first. To take him down you have to target his weakest point - "His Heart". Shoot near around his chest and he should go down pretty quickly. If you have the rocket launcher, you can take down Beliar with around 3-4 rockets aimed at his heart.

Wulf is fast and you have to keep up with him. To take down Wulf just activate your Rage and he should go down pretty easily. I would avoid using guns on Wulf as they do very low damage.

Note that you CAN take down Wulf before Beliar, but you have to do it BEFORE Beliar becomes too big and tears down the roof.

Head Gun: Find the severed head guns



Act 3 - Germany
Level - Of Wulfs and Demons

Strategy - This is a special type of gun which can be only be obtained in the final fight when you face Beliar and Wulf. When the fight starts, go upstairs. Go to a pillar and jump so that you are on the outside edge of it. Jump up and turn around. Now you can see some cages that are hanging from the ceiling of the dome. Shoot all of them down. Now jump up to an even higher ledge (you need to do a backwards jump to reach that ledge (the jump looks like this Ɔ, a flipped C), if you do a normal jump the ceiling will block you). Once you reach the highest ledge you will be given the 'Head Guns'.
If you do this correctly, two head shaped guns will appear in your weapon slots.

And you don't need an empty weapons slot to acquire them, they will replace some existing guns in your inventory.

Half Blood: Complete the game on normal difficulty



Complete the game on Normal difficulty.

Vampiress: Complete the game on hard difficulty



Finish the game on Hard difficulty.

All of the images are taken from the Steam Community.

Thanks to Orlando for the massive help for reviewing and fixing a lot of mistakes I did while writing. Cheers.

I'm not a native English language speaker. English is my second language.
So if I make any grammatical mistake, please write about it in the comments, and I'll fix it.
Thank you.