in the process of passing the game, you can see a scene of a frightened scientist running out to the security guard and saying this same “meme” phrase, while the guard is attacked by zombies and pulls him into the ventilation, which later leads to fatal consequences for both of them

For God's sake, open the silo doors! They're coming for us, it's our only way out! (pause as the security guard is eaten) Oh, my GOD, WE'RE DOOMED!

An example video was taken from the YouTube channel: Sulph