Dio Brando (ディオ・ブランドー Dio Burandō?), known as DIO (DIO (ディオ)?) from Part III onwards, is the main antagonist of both Part I: Phantom Blood and Part III: Stardust Crusaders.

Originally a man of low birth but peerless ambition, Dio is a villain of little conscience, vast cunning, and an insatiable hunger for power.

Dio is father of the protagonist of Part V, Giorno Giovanna as well as many other illegitimate offspring. As the dominant antagonist of the series, his legacy persists throughout the story, officially rounding off in Part VI; though a similar character, Diego Brando, also bears significant influence on Part VII. Like Jotaro Kujo, he's amongst the most well known characters in the series. #MUDA