get 1 ending in every playthrough. we will finish it 4 times in total

we can easily farm and get everything else in the last area (demon of hatred area) in the 4th playthrough. Don't try to farm skill points and you before this because we will get 100 times more in the area I mentioned. Our priority is always to unlock passive skills. Remember, we do not use most active skills.

Try to get the Dancing Dragon Mask early. Don't waste fish scales. We can gain 1 attack power for every 5 skill points. Use it when you are having difficulty and increase your power.

We leave the headless ones for the end game. They are really easy in the end game. It may be beneficial to kill the headless ones early, which only sugar that increase our attack power.

make a list of prayer beads. 40 in total and some in secret places. feel free to look them up on the internet. some can be missed. try to do them all in the first playthrough.

Wow i didn't know i'd have to make multiple run to see everything, I guess I m gonna see some wiki before doing that.

Also while reloading my old save i noticed i didn't fully upgrade everything, altough you said i should wxait my 4th run to farm skill point, I'd like to experiment skill and prothesis, will I really miss nsome fun if i farm skill point before jumping into NG+ ?

Also, should i expect a big leap in difficulety in NG+ ? (i haven't beaten demon of hatred, I stopped at Isshin, The Sword Saint and wondering if i should complete some stuff before my 2nd run, stuff like demon of hatred and probably some other optional bosses I missed, need to check that)

Don't use Dancing Dragon Mask to increase attack power. It will force you to farm skill points that you could have used on your upgrade trees. Kinda important if you want to 100% the game.

At the end of my first play through, I backed up the save before I chose what to do. Then I would choose one option to give to Kuro. After that finished, I would then restore the backup I made, and then make the next choice. Finally, restored the backup and made the final choice to get the three different endings.

But in order to 100% it, you MUST then do NG+. But make sure you've already beaten all the mini-bosses and main bosses (both required and optional) in the first play through. Also, make sure you've collected all the gourds and beads as well. That means you only have to focus on what your choice is when you meet up with Owl in Ashina castle. Depending on what you chose the first play through, you want to choose the other option in NG+.

NG+ is the only way you'll get 100% as you have to beat ALL bosses which is not possible in one play through.