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Note: Unfortunately any death/custom cards & progress you have made when choosing Act 1 tutorial or 2nd option skipping gated progress, none of these are saved & you are purely starting over from a clean slate which includes the reset of the secret card Ouroboros
My Favorite Person on Steam, Just Don't Tell Anyone
Good Luck & Have Fun
One soft spoil that could encourage you to go through act 2 if you want what's next is more horror themed somehow similar to act 1. To me that's well worth it
There is also Kacee's mod you could like if you liked act 1, you can unlock it too by a shortcut but it can also be a reason for you to complete act 2
The best deck in Act 2 is a hybrid Sacrificial/Bone deck, literally the Act 1 deck:
Sacrificial cards are consistent although too many high cost cards is detrimental to the deck.
Bone cards are the best! High attack, disposable (fuels itself), and synergies perfectly w/ sacrificial.
Runes are cool but they're pretty bad, since the damage is poor and HP is almost nil.
Energy is an untapped resource and pretty good, has the highest atk in Act 2.