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I had the same problem starting from a quick save. I loaded an auto save and it works again.

Originally posted by kingkoopazilla:

I had the same problem starting from a quick save. I loaded an auto save and it works again.

i`m not even getting that far. i have checked the integrity of all files and everything was okay.

I uninstalled and reinstalled the game (and Witcher 3). Neither even get to the launcher when I try to launch

I'm having the issue as well. I make it as far as trying to load a save file, and it crashes. This happened on a previous save file, and I went through all the integrity checks, uninstall/reinstall, update files/mods, before just trying the last resort of starting a new game, in case the file was corrupted.

I have noticed one thing in common with both of the "bad" saves mentioned above: Once you get to the interlude, this starts to happen. You can get all the way through Act I, and it is fine. Log in and log out are perfect every time. Once you get to the Interlude, and beyond it won't start up. The first case of a "bad" save I played through the interlude and got into the start of Act II before saving and logging out of the game. Went back in the next day, and the problem started. Just now, on the, now, second "bad" game, I saved at the very beginning of the Interlude, and logged out. Now I can't play the game. Something in the 2.13 patch messed up the game after Act I, is my best guess...